[18F]‐Dopa positron emission tomography imaging in early‐stage, non‐parkin juvenile parkinsonism
Identifieur interne : 004234 ( Main/Exploration ); précédent : 004233; suivant : 004235[18F]‐Dopa positron emission tomography imaging in early‐stage, non‐parkin juvenile parkinsonism
Auteurs : Pramod K. Pal [Canada] ; Joanne Leung [États-Unis] ; Katya Hedrich [Allemagne] ; Ali Samii [Canada] ; Abraham Lieberman [États-Unis] ; Paul A. Nausieda [États-Unis] ; Donald B. Calne [Canada] ; Xandra O. Breakefield [États-Unis] ; Christine Klein [Allemagne] ; A. Jon Stoessl [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-07.
English descriptors
- KwdEn :
- Adolescent, Caudate Nucleus (physiopathology), Caudate Nucleus (radionuclide imaging), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), DNA Mutational Analysis, Dihydroxyphenylalanine (analogs & derivatives), Dihydroxyphenylalanine (diagnostic use), Dominance, Cerebral (physiology), Gene Expression (physiology), Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Ligases (genetics), Male, Neurologic Examination, PET, Parkinson's disease, Parkinsonian Disorders (genetics), Parkinsonian Disorders (radionuclide imaging), Putamen (physiopathology), Putamen (radionuclide imaging), Tomography, Emission-Computed (methods), Ubiquitin-Protein Ligases, dopamine, genetics, parkin.
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , diagnostic use : Dihydroxyphenylalanine.
- chemical , genetics : Ligases.
- genetics : Parkinsonian Disorders.
- methods : Tomography, Emission-Computed.
- physiology : Dominance, Cerebral, Gene Expression.
- physiopathology : Caudate Nucleus, Corpus Striatum, Putamen.
- radionuclide imaging : Caudate Nucleus, Corpus Striatum, Parkinsonian Disorders, Putamen.
- Adolescent, DNA Mutational Analysis, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Male, Neurologic Examination, Ubiquitin-Protein Ligases.
Abstract
There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F‐6‐fluoro‐L‐dopa (FD) PET in a 14‐year‐old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult‐onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10133
Affiliations:
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Pal</name></author><author><name sortKey="Leung, Joanne" sort="Leung, Joanne" uniqKey="Leung J" first="Joanne" last="Leung">Joanne Leung</name></author><author><name sortKey="Hedrich, Katya" sort="Hedrich, Katya" uniqKey="Hedrich K" first="Katya" last="Hedrich">Katya Hedrich</name></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></author><author><name sortKey="Lieberman, Abraham" sort="Lieberman, Abraham" uniqKey="Lieberman A" first="Abraham" last="Lieberman">Abraham Lieberman</name></author><author><name sortKey="Nausieda, Paul A" sort="Nausieda, Paul A" uniqKey="Nausieda P" first="Paul A." last="Nausieda">Paul A. Nausieda</name></author><author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. 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Nausieda</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>NPF Centre of Excellence, St. Joseph's Hospital, Milwaukee, Wisonsin</wicri:regionArea><wicri:noRegion>Wisonsin</wicri:noRegion></affiliation></author><author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, Vancouver Hospital & Health Sciences Centre, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Breakefield, Xandra O" sort="Breakefield, Xandra O" uniqKey="Breakefield X" first="Xandra O." last="Breakefield">Xandra O. Breakefield</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Departments of Neurology and Human Genetics, Medical University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Neurodegenerative Disorders Centre, Vancouver Hospital & Health Sciences Centre, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-07">2002-07</date><biblScope unit="vol">17</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="789">789</biblScope><biblScope unit="page" to="794">794</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9BDECF2998366AABC8507B54BB973B0C958241A1</idno><idno type="DOI">10.1002/mds.10133</idno><idno type="ArticleID">MDS10133</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Caudate Nucleus (physiopathology)</term><term>Caudate Nucleus (radionuclide imaging)</term><term>Corpus Striatum (physiopathology)</term><term>Corpus Striatum (radionuclide imaging)</term><term>DNA Mutational Analysis</term><term>Dihydroxyphenylalanine (analogs & derivatives)</term><term>Dihydroxyphenylalanine (diagnostic use)</term><term>Dominance, Cerebral (physiology)</term><term>Gene Expression (physiology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Imaging, Three-Dimensional</term><term>Ligases (genetics)</term><term>Male</term><term>Neurologic Examination</term><term>PET</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (genetics)</term><term>Parkinsonian Disorders (radionuclide imaging)</term><term>Putamen (physiopathology)</term><term>Putamen (radionuclide imaging)</term><term>Tomography, Emission-Computed (methods)</term><term>Ubiquitin-Protein Ligases</term><term>dopamine</term><term>genetics</term><term>parkin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Dihydroxyphenylalanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Gene Expression</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term><term>Corpus Striatum</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Caudate Nucleus</term><term>Corpus Striatum</term><term>Parkinsonian Disorders</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>DNA Mutational Analysis</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Neurologic Examination</term><term>Ubiquitin-Protein Ligases</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F‐6‐fluoro‐L‐dopa (FD) PET in a 14‐year‐old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult‐onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li><li>Massachusetts</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Pal, Pramod K" sort="Pal, Pramod K" uniqKey="Pal P" first="Pramod K." last="Pal">Pramod K. Pal</name></noRegion><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Leung, Joanne" sort="Leung, Joanne" uniqKey="Leung J" first="Joanne" last="Leung">Joanne Leung</name></region><name sortKey="Breakefield, Xandra O" sort="Breakefield, Xandra O" uniqKey="Breakefield X" first="Xandra O." last="Breakefield">Xandra O. Breakefield</name><name sortKey="Lieberman, Abraham" sort="Lieberman, Abraham" uniqKey="Lieberman A" first="Abraham" last="Lieberman">Abraham Lieberman</name><name sortKey="Nausieda, Paul A" sort="Nausieda, Paul A" uniqKey="Nausieda P" first="Paul A." last="Nausieda">Paul A. Nausieda</name></country><country name="Allemagne"><noRegion><name sortKey="Hedrich, Katya" sort="Hedrich, Katya" uniqKey="Hedrich K" first="Katya" last="Hedrich">Katya Hedrich</name></noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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